The following is an essay originally submitted for publication in a book on philosophy and psychedelics. After some feedback from the editors, I realized it is too long and includes too many (I hope interesting!) digressions. I’ll be thoroughly revising my submission for the book, so I figured I’d share this earlier version here. Feedback welcome!

Abstract: The study of consciousness is today’s most exciting philosophical frontier. Such an inquiry provides an obvious example of the relevance of psychedelic experience: what better way could there be for coming to terms with the intimate mystery our own consciousness than through the ingestion of psychedelic—literally, “mind-manifesting”—chemicals? In the chapter to follow, I offer a creative reading of Rene Descartes’ Meditations on First Philosophy, reinterpreting his famous Gedankenerfahrung (“thought-experiment”) as a sort of psychedelic trip through hell and heaven and back again. I next turn to Whitehead’s process-relational reimagining of modern Cartesian philosophy, detailing how his approach more adequately incorporates the psychedelic ground of consciousness. I argue that Whitehead’s philosophy of organism opens up the possibility of a psychedelic realism that would allow us to take the ontologically revelatory nature of these experiences seriously. My hope is that this comparative reading of Descartes and Whitehead opens up a road not taken by modern natural science and philosophy, one leading away from the self-alienation and cosmic disenchantment that have so plagued contemporary science and society. Self-integration and world re-enchantment are possible. Ingested responsibly and in service of philosophical inquiry, psychedelics may act as alchemical catalysts providing an especially powerful medicinal aid in service of this Great Work.